Kafukufuku watsopano akupititsa patsogolo nkhani zolimbitsa thupi zolimbikitsa unyamata

Pepala laposachedwa lofalitsidwa mu Journal of Physiology lakulitsa mlandu wolimbikitsa unyamata wochita masewera olimbitsa thupi pazamoyo zokalamba, kumanga pa ntchito yam'mbuyomu yomwe idachitidwa ndi mbewa za labu pafupi ndi kutha kwa moyo wawo wachilengedwe womwe umakhala ndi gudumu lolemetsa.

Pepala latsatanetsatane, "Siginecha ya molekyulu yofotokozera zolimbitsa thupi ndi ukalamba komanso mu vivo pang'ono reprogramming mu skeletal muscle," imatchula olemba anzawo 16, asanu ndi mmodzi omwe ali ogwirizana ndi U of A. Wolemba nawo ndi Kevin Murach, pulofesa wothandizira mu U of A's Department of Health, Human Performance and Recreation, ndipo wolemba woyamba ndi Ronald G. Jones III, Ph.D.wophunzira ku Murach's Molecular Muscle Mass Regulation Laboratory.

Pa pepalali, ochita kafukufuku anayerekezera mbewa zokalamba zomwe zinkakhala ndi gudumu lochita masewera olimbitsa thupi ndi mbewa zomwe zinakhalapo ndi epigenetic reprogramming kudzera muzinthu za Yamanaka.

Zinthu za Yamanaka ndi zinthu zinayi zolembera mapuloteni (omwe amadziwika kuti Oct3/4, Sox2, Klf4 ndi c-Myc, omwe nthawi zambiri amafupikitsidwa ku OKSM) omwe amatha kubwezeretsa maselo odziwika bwino (monga khungu la khungu) kubwerera ku cell cell, yomwe ndi achichepere komanso osinthika kwambiri.Mphotho ya Nobel mu Physiology kapena Medicine idaperekedwa kwa Dr. Shinya Yamanaka chifukwa chopeza izi mu 2012. Mlingo wolondola, kuyambitsa zinthu za Yamanaka m'thupi lonse mu makoswe kumatha kuwongolera zizindikiro za ukalamba potengera kusinthasintha komwe kumachitika kwa achinyamata ambiri. maselo.

Pazifukwa zinayi, Myc imayambitsidwa ndikuchita masewera olimbitsa thupi.Myc ikhoza kukhala ngati chiwongolero chotsitsimutsa mwachilengedwe mu minofu, ndikupangitsa kuti ikhale yothandiza poyerekeza pakati pa maselo omwe adakonzedwanso kudzera m'mawu a Yamanaka ndi ma cell omwe adakonzedwanso pochita masewera olimbitsa thupi - "reprogramming" pamapeto pake akuwonetsa momwe kukondoweza kwa chilengedwe kungasinthe kupezeka ndi kuwonetsera kwa majini.

Ofufuzawo anayerekezera chigoba cha mbewa zomwe zinaloledwa kuchita masewera olimbitsa thupi mochedwa m'moyo ndi minofu ya mbewa yomwe inadutsa OKSM mu minofu yawo, komanso mbewa zosinthidwa ma genetic zomwe zimangowonjezera kupitirira kwa Myc mu minofu yawo.

Pamapeto pake, gululo lidatsimikiza kuti masewera olimbitsa thupi amalimbikitsa mbiri ya maselo yogwirizana ndi pulogalamu ya epigenetic partial.Izi zikutanthauza kuti: masewera olimbitsa thupi amatha kutsanzira mbali za maselo a minofu omwe awonetsedwa ndi Yamanaka factor (motero amasonyeza makhalidwe a maselo a maselo achichepere).Kupindula kochita masewera olimbitsa thupi kumatha kukhala chifukwa cha zomwe Myc amachita mu minofu.

Ngakhale kuti zingakhale zophweka kuganiza kuti tsiku lina tikhoza kugwiritsa ntchito Myc mu minofu kuti tikwaniritse zotsatira za masewera olimbitsa thupi, motero kutiteteza ife kugwira ntchito mwakhama, Murach akuchenjeza kuti zingakhale zolakwika.

Choyamba, Myc sangathe kubwereza zonse zomwe zimachitika m'munsi mwa thupi lonse.Ndiwonso umayambitsa zotupa ndi khansa, kotero pali zoopsa zomwe zimatengera kuwongolera mawonekedwe ake.M'malo mwake, Murach akuganiza kuti kugwiritsa ntchito Myc kungagwiritsidwe ntchito bwino ngati njira yoyesera kumvetsetsa momwe mungabwezeretsere masewero olimbitsa thupi ku minofu yakale yomwe ikuwonetsa kuchepa kwa kuyankha.Mwinanso ikhoza kukhala njira yowonjezerera kuyankha kwa oyenda mumlengalenga mu zero yokoka kapena anthu omwe amangogona pabedi omwe ali ndi mphamvu zochepa zochitira masewera olimbitsa thupi.Myc ili ndi zotsatira zambiri, zabwino ndi zoipa, kotero kufotokozera zopindulitsa kungapangitse chithandizo chamankhwala chotetezeka chomwe chingakhale chothandiza kwa anthu pamsewu.

Murach amawona kafukufuku wawo ngati kutsimikiziranso kolimbitsa thupi ngati polypill."Kuchita masewera olimbitsa thupi ndi mankhwala amphamvu kwambiri omwe tili nawo," akutero, ndipo ayenera kuonedwa kuti ndi olimbikitsa thanzi - komanso omwe angakhale otalikitsa moyo - chithandizo pamodzi ndi mankhwala ndi zakudya zabwino.

Olemba nawo a Murach ndi Jones ku U of A adaphatikizapo pulofesa wa sayansi ya masewera olimbitsa thupi Nicholas Greene, komanso ochita kafukufuku Francielly Morena Da Silva, Seongkyun Lim ndi Sabin Khadgi.